The Best Vitamins to Take While on Semaglutide

You finally decided to do something for yourself. Maybe it was a quiet moment after the kids went to bed, or a morning when your jeans felt a little tighter than you remembered. Whatever it was, you took that first brave step — and you started your weight-loss journey with Semaglutide.

Now, a few weeks in, you might be thinking, “Wait… why am I so tired?” or “My hair feels thinner,” or even “I’m losing weight, but I don’t feel as energetic as I expected.”

You’re not imagining it — and you’re definitely not alone.
While Semaglutide is one of the most effective medicines for weight loss, your body is adjusting in big ways. Appetite changes, hormonal shifts, and new nutrient needs are all part of the process.

That’s where vitamins and supplements come in — not as “extras,” but as real tools to keep your body balanced while you lose weight safely.

At Alternate Health Club (AHC), we see women every day who are transforming their health with Semaglutide — and learning how to support that transformation with the right nutrition and supplement strategy. So today, let’s unpack what your body actually needs, how to restore your energy, and the best vitamins to take while on Semaglutide to keep your hair, metabolism, and confidence thriving.

Why Supplements Matter When You’re on Semaglutide

Semaglutide changes the way your body processes food, hunger, and energy. It slows digestion and reduces your appetite — which is great for fat loss, but it can also mean you eat less overall. When food intake drops, your vitamin and mineral intake can dip too.

Over time, this can show up as:

• Fatigue or sluggish energy
  
• Hair thinning or dull skin
  
• Low mood or brain fog
  
• Muscle weakness or cramps
  

The truth is simple: while Semaglutide helps with weight loss, your body still needs the fuel to function at its best. Adding targeted Semaglutide supplements for women helps fill those gaps, making your journey smoother and your results more sustainable.

The Best Vitamins to Take While on Semaglutide

Think of your supplement routine as a wellness checklist for your body. Here’s what to prioritise:

1. B-Complex Vitamins: Your Daily Energy Backup

If you’ve been feeling more tired or “foggy,” you’re not crazy — it’s one of the most common side effects women notice on Semaglutide.

The reason? You’re eating less food, so you’re also getting fewer B vitamins. These nutrients are essential for turning food into energy, supporting metabolism, and keeping your nervous system balanced.

Why they matter:

• B12 supports energy and focus
  
• B6 helps with mood and metabolism.
  
• Folate (B9) supports hormonal balance and red blood cell health.h
  

You can find B vitamins in foods like eggs, leafy greens, and salmon — but a B-complex supplement is the easiest way to stay steady, especially if you’re on a calorie-restricted plan.

At Alternate Health Club, we often pair Semaglutide with B12 injections or oral B-complex blends to help women feel energised again within days.

2. Vitamin D: The Sunshine Nutrient Most Women Miss

Here’s something few people talk about — Vitamin D is one of the most common deficiencies in women, and Semaglutide doesn’t help. When you lose weight, fat cells release stored hormones and vitamins, including D. This means your body might burn through it faster than usual.

Low Vitamin D can show up as:

• Low mood
  
• Muscle pain or weakness
  
• Slower metabolism
  
• Hair shedding
  

Why it matters:
Vitamin D helps regulate insulin, balance hormones, and improve how your body processes fat. It also supports your immune system and bone health — all critical while your body adjusts to new rhythms.

Try to get sunlight when you can, but consider supplementing with 2,000–5,000 IU of Vitamin D3 daily after checking your levels.

3. Magnesium: The Unsung Hero for Rest, Mood, and Digestion

You know that heavy, restless feeling before bed? Or when your digestion just feels “off”? That’s often a sign your magnesium is low.

Semaglutide users often experience mild constipation or sluggish digestion because of slower gastric movement — magnesium can help with that while also relaxing your muscles and easing anxiety.

Why it matters:

• Helps with stress, sleep, and mood
  
• Supports muscle recovery and gut motility
  
• Balances electrolytes when your appetite changes
  

Magnesium glycinate or citrate forms are best for daily use. AHC often includes magnesium as part of our women’s supplement kits to help with Semaglutide fatigue and smooth digestion.

4. Biotin and Collagen: For Hair, Skin, and Confidence

One of the hardest things women tell us about their weight-loss journey isn’t hunger — it’s hair. Losing even a little extra hair can feel discouraging when you’re finally doing something right for your body.

This is where biotin, collagen peptides, and silica-rich supplements shine. They help your hair follicles grow stronger and your skin stay hydrated during rapid fat loss.

Why they matter:

• Biotin (Vitamin B7) supports keratin production for stronger hair
  
• Collagen improves skin elasticity and joint health.
  
• Zinc and Vitamin C help repair tissue and prevent breakage.e
  

If you’re noticing more strands in your brush or a dull complexion, don’t panic. It’s usually temporary and reversible with the right support.
Check out our detailed guide on fatigue and nutrition here:
👉 Semaglutide Fatigue: Understanding and Overcoming This Side Effect

5. Iron: The “Hidden” Energy Fix

Women, especially those in their 30s and 40s or postpartum, are at higher risk of low iron. When you pair that with lower food intake, it can make fatigue hit even harder.

Iron helps carry oxygen through your blood, supporting metabolism and muscle function — both vital when you’re trying to stay active on your weight-loss journey.

If you’ve been feeling unusually winded during workouts or light-headed, talk to your doctor about checking your ferritin levels. Adding an iron supplement (with Vitamin C for absorption) can make a dramatic difference in your stamina and mood.

6. Electrolytes: Because Water Isn’t Always Enough

Hydration isn’t just about how much water you drink — it’s about how well your body absorbs it. When you eat less and drink more, your body flushes out minerals like sodium, potassium, and magnesium faster than before.

That’s why so many Semaglutide users feel dizzy, tired, or headachy early on — they’re missing electrolytes.

Quick fix:
Add a clean electrolyte powder or drops to your water daily. Look for ones without added sugar or artificial sweeteners. Coconut water is another gentle way to hydrate naturally.

Hydration + electrolytes = fewer headaches, better workouts, and a more stable mood.

Vitamins That Help You Feel Like “You” Again

Let’s be honest: weight loss isn’t just physical. It’s emotional.
When you finally start losing pounds after months (or years) of trying, it feels amazing — but if you’re exhausted, moody, or your hair’s falling out, it can steal your joy.

That’s why Semaglutide supplements for women should focus on how you feel just as much as how you look.

Try this simple daily rhythm:

Morning:

• B-Complex + Vitamin D3
  
• Glass of water with electrolytes
  
• Protein-rich breakfast (Greek yoghurt, eggs, or protein smoothie)
  

Afternoon:

• Magnesium + Iron (if prescribed)
  
• Balanced lunch with greens, lean protein, and healthy fats
  
• Short walk or stretch — helps energy and digestion.
  

Evening:

• Collagen in tea or water
  
• 7–8 hours of rest (your metabolism depends on it!)
  

If you’re not sure how to eat while using Semaglutide, this guide is a must-read:
👉 What to Eat on Semaglutide: Top Food Choices for Weight Loss and Health

How Fatigue, Hormones, and Nutrition Interact

If you’ve ever wondered why your energy dips when you’re doing “everything right,” it often comes back to hormones. Semaglutide changes the way your body uses insulin, which can also affect estrogen, cortisol, and thyroid balance.

When these hormones fluctuate, so do your energy levels — and sometimes your mood.
That’s where vitamins play a stabilising role:

• B vitamins + magnesium calm stress hormones
  
• Iron + Vitamin D supports thyroid function.
  
• Zinc + collagen promote healthy hair and skin.
  
• Electrolytes + hydration improve focus and reduce brain fog.g
  

Every small correction adds up to feeling more like yourself again — centred, clear, and steady.

Bonus Support: NAD+ for Energy and Longevity

If you’re already thinking long-term (and we know you are), consider pairing your vitamin plan with NAD+ therapy — a coenzyme that fuels your cells’ natural energy production.

At Alternate Health Club, many women combine NAD+ injections with GLP-1 therapy to enhance metabolism and restore focus during their weight-loss journey.

It’s not about doing “more.” It’s about doing what’s right for your body so you can feel energised, not drained, while transforming your health.

If you’re curious about this combination, our recent post explains it clearly:
👉 Can I Take NAD+ and Tirzepatide Together?

Building a Health-First Mindset

Weight loss isn’t punishment. It’s healing.
But healing takes patience, and patience needs nourishment.

Here’s what we tell every woman who joins our AHC family:

• Your journey is personal. You’re not on anyone’s timeline but your own.
  
• Your body is intelligent. It responds to care, not criticism.
  
• Your energy matters. Losing weight shouldn’t mean losing yourself.
  

The best vitamins to take while on Semaglutide are the ones that help you live your daily life fully — chasing your kids, working, laughing, sleeping deeply, and waking up with energy to do it again.

You deserve that.

When to Seek Professional Support

If you’re unsure what your body needs, don’t guess — test.
Our clinicians at Alternate Health Club create personalised supplement and medication plans for women on Semaglutide, tailored to your:

• Hormone profile
  
• Sleep and stress patterns
  
• Nutrition gaps
  
• Weight-loss goals
  

We look beyond the scale to design a program that supports you as a whole person.
That includes diet, hydration, vitamins, and stress management — because all of it connects.

If you’d like to learn more about safe dosing and progress tracking, start here:
👉 Compounded Semaglutide Weight Loss Dosage Chart: A Comprehensive Guide

The Takeaway

Your health journey deserves more than shortcuts. It deserves care.

Semaglutide gives your body the signal to change. Vitamins give it the strength to keep going. When you combine the two, you don’t just lose weight — you gain energy, confidence, and long-term wellness.

If you’ve been feeling sluggish, hair-thin, or emotionally flat, remember this isn’t failure. It’s feedback from your body asking for balance — and now you know how to give it what it needs.

At Alternate Health Club, we’re here to make sure your journey feels as good as your results look.
Because true transformation isn’t just about pounds lost — it’s about life gained.